CONCLUSIONS: We have conceptualised two immune mediator-informed indexes, the LCRII that predicts SLE from months to years before clinical presentation, and the LDAII that analogously predicts active disease in SLE to distinguish patients who would benefit from early intervention.

Hypermobile Ehlers-Danlos Syndrome (hEDS) is a complex, underdiagnosed connective tissue disorder characterized by widespread symptoms affecting multiple organ systems. Recent clinical observations suggest that individuals with hEDS may be at increased risk for persistent symptoms following COVID-19, commonly referred to as Long COVID. Using data from over 23 million patients across the United States, we examined associations between hEDS, COVID-19 infection, Long COVID, and related chronic...

Prediabetes increases oxidative stress and the risk of type 2 diabetes and related cardiovascular diseases. Previous trials have shown antioxidant-rich strawberries improve this risk, but effects on antioxidant markers are inconclusive. This 28-week randomized controlled crossover trial evaluated the effects of freeze-dried strawberries (FDS) on fasting glucose, serum antioxidant status, and vascular inflammation in adults with prediabetes not on glucose-lowering medications. Participants were...

CONCLUSIONS: This study suggests that, for similarly injured patients, massive transfusion, airway management, hemorrhage control via laparotomy, and other cardiac procedures performed at TTCs explain most of the observed survival benefit for patients treated at TTCs.

CONCLUSIONS: The study identifies novel associations between surfactant protein gene SNPs and ROP risk that may impact protein structure, function in the retinal vasculature.

Previous studies demonstrated higher short-term mortality among rural compared with urban residents infected with SARS-CoV-2. However, whether this difference persists remains uncertain. This retrospective cohort study analyzed two-year post-COVID-19 mortality by rurality using the National Clinical Cohort Collaborative COVID-19 Enclave, a United States-based longitudinal electronic health record repository. We analyzed mortality among patients infected with SARS-CoV-2 between April 2020 and...

Sjögren's disease (SjD) targets the salivary and lacrimal glands and is characterized by autoantibody production and glandular lymphocytic infiltrate with ectopic germinal centers (EGCs). The chemokine CCL25 recruits CCR9^(+) CD4^(+) T cells to the salivary glands to promote B cell activation. However, the therapeutic potential of targeting the CCL25-CCR9 axis to limit glandular inflammation and lymphoid neogenesis remains largely unexplored. Evaluate whether blocking the CCL25-CCR9^(+) T cell...

Improving detection of smoking lapse risk factors could increase smoking cessation rates among socioeconomically disadvantaged adults, who are less likely to quit than the general population. This study used data from a randomized controlled trial that compared the efficacy of two smartphone-based smoking cessation interventions for socioeconomically disadvantaged adults. Daily ecological momentary assessments (EMAs) assessed current smoking lapse risk based on a previously developed algorithm....

CONCLUSION: Although the Study of Antimalarials in Incomplete Lupus Erythematosus (SMILE) did not show effects of HCQ on ILE progression, the results offer insights into SLE risk in the ILE population.

CONCLUSIONS: Although some prior observational studies suggested that Paxlovid held promise as a PASC preventive, this study-with a large, nationally sampled cohort; a contemporary study period; and causal inference methodology-found that Paxlovid treatment during acute COVID-19 had no effect on subsequent PASC incidence. Stratified analyses suggest that Paxlovid may have a small protective effect among higher-risk patients, but the NNT is high. In conclusion, we see Paxlovid as unlikely to...

BACKGROUND: Long COVID affects a substantial portion of the U.S. population, yet its spatiotemporal distribution remains poorly characterized. The emergence of the Omicron variant and persistent sociodemographic disparities may contribute to regional variation in long COVID risk. Understanding the patterns of long COVID is essential to implementing targeted and equitable public health interventions.

Several non-invasive biomarkers for paediatric metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported, but no prior studies directly compared multiple protein or microRNA (miRNA) markers of liver health in adolescents with and without MASLD and determined which serum markers are associated with liver histopathological features. We measured 6 serum protein and 4 miRNA candidates in 3 groups of participants: 23 with obesity and biopsy-proven MASLD, 24 controls with...

We examined the of-preposition in language samples because it is a highly variable feature that can be marked or unmarked (e.g., "out [of] the door") depending on context. Children who speak African American English (AAE) produce unmarked of-prepositions in contexts that are universal across AAE and General American English (GAE; e.g., "out [of] the window") and in contexts specific to the AAE dialect (e.g., "out [of] the car"). Guidance in the literature on this variability is limited for...

BACKGROUND: In 2021, we used the National COVID Cohort Collaborative (N3C) as part of the National Institutes of Health RECOVER Initiative to develop a machine learning pipeline to identify patients with a high probability of having post-acute sequelae of SARS-CoV-2 infection or long COVID. However, the increased home testing, missing documentation, and reinfections that characterise the pandemic beyond 2022 necessitated the re-engineering of our original model to account for these changes in...