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Evidence describing paediatric COVID-19 and influenza co-infection is limited because influenza circulation was minimal during the early COVID-19 pandemic. We used the National Clinical Cohort Collaborative, a multicentre electronic health record repository, to describe the characteristics and clinical outcomes of paediatric COVID-19 and influenza co-infections in the United States from March 2020-April 2024. We defined co-infection as COVID-19 and influenza identified <7 days apart. We reported...

INTRODUCTION: American Indian/Alaska Native (AI/AN) communities experience persistent oral health disparities shaped by a range of social determinants of health (e.g., social, economic, and healthcare access factors). However, associations between demographic and socioeconomic characteristics and oral health outcomes among AI/AN populations remains understudied. The objective of this study was to conduct an exploratory analysis of demographic and socioeconomic factors and oral health outcomes...

BACKGROUND: Vaccination is a vital tool in preventing acute COVID-19 and may confer additional protection against Long COVID, although it is unclear whether this protection wanes over time.

CONCLUSIONS: These findings support the hypothesis that metformin prescription during acute COVID-19 may be associated with lower mortality among adults with diabetes. These analyses also provide modest evidence of a protective association against Long COVID in adults with diabetes, although estimates were imprecise.

CONCLUSIONS: We found that among individuals with type 2 diabetes and comorbid COVID-19, a prescription for GLP vs. SGLT2i medications was associated with a lower risk of mortality, but not Long COVID.

BACKGROUND: Long COVID is a syndrome characterized by symptoms and conditions across all biological systems. This breadth of Long COVID phenotypes impedes efforts to identify the mechanistic pathways of Long COVID. Low serotonin may play a role in long-term sequelae of COVID-19, and selective serotonin reuptake inhibitors (SSRIs) may prevent these sequelae. Evaluation of the relationship between SSRIs and distinct categories of symptoms and conditions associated with Long COVID can highlight the...

CONCLUSIONS: Tobacco-related cancers remain prevalent in Oklahoma, especially among males, rural, and AI/AN populations. Although incidence is declining, disparities persist. These findings underscore the ongoing need for targeted tobacco control efforts to address inequities and reduce cancer burden.

CONCLUSION: Obesity-related cancers constitute a significant proportion of the cancer burden in Oklahoma. Disparities by sex, race, socioeconomic status, and geography underscore the need for targeted prevention and education strategies. Public awareness campaigns and health policy interventions addressing obesity may help reduce cancer incidence in high-risk populations.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease in children and adolescents. Assessment of circulating biomarkers is needed to understand the underlying pathology, disease severity, and treatment options. The secreted hepatokine Tsukushi (TSK) is involved in lipid and carbohydrate metabolism. TSK is increased in adults with MASLD but has yet to be reported in adolescents. We hypothesized that plasma TSK is increased in adolescents with MASLD...

CONCLUSIONS: This systematic review and consensus guidelines for LDRT treatment of OA are based on current evidence. Further high-quality studies are warranted.